King David Essay Example | Topics and Well Written Essays - 3000 words

King David - Essay Example David was a youthful military leader prior to his kingship. His leadership would liberate Israel from the cold hearted culture developed by the first king that Israelites had chosen to lead them in rebellion, because they could not hold and wait for God’s purpose and timing. According to the bible, David was a King that at times experienced failure in his humanity, yet as told he still sought God with his whole heart. However, today there are those that would say that David’s Kingdom and David were indeed Israel’s imagination and a legendary military hero that never existed in the actual sense. Liberal critical consensus about David has long been that he was a legendary figure in the history of Israel. There are scholars that often stress that the stories on King David are mere embellishments of a national hero whose existence is not in history is not certain (Huyck, 1). For example, Kyle McCarter states that: â€Å"The Bible is our only source of information ab out David.   No ancient inscription mentions him.   No archaeological discovery can be securely linked to him. . . .We cannot assume, therefore, that a statement about David in a given part of the Bible derives from an early source.   The David of Chronicles, for example, is the idealized David of the second Commonwealth, not the David of history (Huyck, 1).† Contrary to this statement and many others like it, archeological evidence has tallied with most historical mentioning within the bible and other historical literature and findings to prove that indeed the Kingdom of David and David as king existed at some point in history. This has strengthened the biblical view and story that indeed David was not a mere myth, but true King that existed and left a legendary mark in the history if Israel (Huyck, 1). The first recently highlighted and iconic archeological finding that attested to this occurred seven years after the discovery of the Solomonic gate by the Mazars. In th at instance in 1993, an archaeological team digging in the northern part of Israel discovered a large stone tabled with inscriptions that read: â€Å"House of David â€Å"and â€Å"King of Israel.† This stunning uncovered piece of evidence was dated back to the 9th Century B.C. This is indeed one of the many uncovered evidence that proofs that David’s kingdom not only existed, but his reign started a royal dynasty. The twelve acre triangle city developed by David’s reign lay some 350 feet, south of the today’s walled Jerusalem, beyond and on the eastern ridge known as Ophel. Benjamin Mazar is quoted by the Associated Press, as having said that: â€Å"Now we have more or less the feeling that this is really a gate of Jerusalem from the period of the kings of Judah† (April 21, 1986). This leaves most people wondering as to whether archaeology is indeed coming up to fill the bits and prove the biblical history that recounts the life and leadership o f David. Eilat Mazar indeed attests to this statement by saying that she had learned to pore and relate to biblical text to an extent that she had discovered that indeed it makes descriptions of true historical reality. Eilat states that: â€Å"It is not a simple matter to differentiate the layers of textual sources that have been piled†¦over generations; but it is clear that concealed within the Biblical text are grains of detailed historical truth (Coogan 71).†

Managing Through People Assignment Example | Topics and Well Written Essays - 2000 words

Managing Through People - Assignment Example ions, including, eg, career development, training, organization development, etc.†1 Human resource Management (HRM) is the management activity of the employees of an organization where as the Human Resource Development (HRD) is a more general term in which apart from the management function the developments of the organization and the employees (internal and external) through different types of training activities are also the functions of an HRD department. The globalized current business environment has made the task complicated for the HR department. Most of the companies are now establishing their manufacturing units in overseas countries in order to exploit the overseas markets. Some employees need to be sent to the overseas countries in order to set up the business there. The HR managers need to train such employees in accordance with the needs of the target country. The difference in culture, language, environment all must be addressed by the HR managers while formulating the training procedures. Microsoft is believed to be one of the biggest software companies in the world. In fact it controls the majority of the world’s software market with their monopoly. Even other companies like Intel were forced to make microprocessor chips suitable for the Microsoft’s Windows operating system because of their monopoly. Microsoft did this by creating a series of operating systems (DOS, then Windows), and by defining the kind of machine that could run their OSs.† (Why is Microsoft a Monopoly?) Microsoft is lead by its founder Bill Gates. It is actually the great leader ship Bill Gates, shaped Microsoft into such a big monopolistic firm in the world. â€Å"Leadership is setting a new direction or vision for a group that they follow, ie: a leader is the spearhead for that new direction. Management controls or directs people/resources in a group according to principles or values that have already been established.†2 The leader always concentrated on setting the

Combination of Microsoft Dynamics and Microsoft BizTalk Server Research Paper

Combination of Microsoft Dynamics and Microsoft BizTalk Server - Research Paper Example This research will begin with the statement that Microsoft Corporation is an American based multination corporation with its headquarters in Redmond, Washington. Microsoft is a business empire that develops, supports manufacturers, and licenses numerous products and services that are related to computing. Paul Allen and Bill Gates founded Microsoft Company on April 4, 1945.   Since then, Microsoft Corporation has grown to be the world’s largest software manufacturer by revenue. Notably, Microsoft Corporation is one of the most valuable companies in the world. Microsoft was established to manufacture and sell the Altair 8800 BASIC interpreters. In the mid-1980s, this company ventured into selling personal computers operating systems, particularly the MS-DOS. This was followed by Microsoft Windows operating systems. In the year 1986, Microsoft initiated public offering that led to the rise in its share prices. Since the early 1990s, Microsoft Corporation has increasingly diver sified into numerous operating system markets that have made it acquire numerous corporates. For instance, in May 2011, it acquired Skype Technologies at the value of $8.5 billion, and Skype has been Microsoft’s largest acquisition since its advent. Notably, Microsoft’s key business process is remarkably candid in that it develops software then distributed to users who purchase either directly from the Microsoft Corporation or through the company's outlet agencies or companies that have rights to sell through them.... Nonetheless, the Microsoft’s workflow diagram can be presented as in the diagram below: Microsoft’s Business Operations Microsoft Dynamics This is a business management solution that aims at streamlining and automating financial and customer relationship as well as supply chain processes in order to derive Microsoft’s businesses to success (Griffin, 2012). Microsoft dynamics is integrated business management solution that was adapted by the organization to enable it to make business decisions with immense confidence (Ward, 2012). Automation and streamlining of customer relationship, financial and supply chain processes through Microsoft Dynamics enables the organization to consolidate technologies, processes, and people towards increasing effectiveness and productivity of the business as well as driving the business to be driven to success. The Microsoft Dynamics operates in the same ways as other Microsoft software such as Microsoft office; thereby, it decreases the staff extensive learning requirements (Page, 2010). Notably, the Microsoft Dynamics software easily works with other systems already installed and implement in the organization. The Microsoft BizTalk Server Microsoft BizTalk Server is a process management server that helps the organization to connect to processes, information, and people across extended enterprises. The Microsoft BizTalk Server enables the organization to optimize and automate its business processes; thus, helping it to grow. The Microsoft BizTalk Server was introduced in the year 2006 and has enable Microsoft to expose its data and processes in real time. Moreover, this system has helped the organization to decrease costs, optimize business

Personal Statament for Bsc Drama School (Acting and some applications Statement

Statament for Bsc Drama School (Acting and some applications Mucical Theatre) - Personal Statement Example I had no passion in the job and so I had to quit and pursue acting. Recently, I got involved in armature theatre production and I have never been happier! I straight away new that this is where I want to be for the rest of my life. I feel that I have a lot to give. I am energetic, creative and emotional person with high energy levels. I have an enormous desire to learn the art of acting and it makes me truly content with myself. I feel I am able to capture the attention of the audience and through the knowledge I will get I will be able to perfect my skills and work to achieve better results. This coupled with my creative nature will boost my prospects and help me deliver amicably in acting filed in forthcoming years. There are some key concepts that I have learnt that will be important once I become active in drama. The first one is time keeping. Drama is a demanding career that requires ample time to rehearse and memorise the episodes that one will be involved in. This therefore calls for good time management skills that will ensure that I am always there in time to avoid missing any bit. Another concept is being organised. I have learnt to be organised as an actor as the picture one portrays to the audience may determine the success of the production. I have confidence and I a good communicator and I feel this will also work positively to boost my prospects as I work to become a high profile actor. Drama often involves working in a team. Having good communication skills ensures that one is able to fit in any team and deliver his mandate effectively. I will therefore use this to make my career in acting better. I have come to realize that life is not about the job which is the most financially rewarding but about realizing yourself in the field that one loves and can deliver the best it. So, I feel that now I have the maturity and experience to

How does al etihad company benefit from the employment from overseas Research Proposal

How does al etihad company benefit from the employment from overseas graduates - Research Proposal Example al., 2013). Subsequently, the proposed study will help identifying how the company will be benefitted from recruiting skilled and talented graduates of the overseas labour market. This outcome of the proposed study will be crucial in determining a better set of workforce that can contribute towards the sustainable existence of the overall business (Gold Bars Worldwide, 2013). A better understanding of the research topic can be gained from the brief analysis of secondary sources. As per Chandramohan (2008), HRM ensures proper and productive management of the resources in businesses, deemed as the most vital assets required for the sustainability of any organisation (Chandramohan, 2008). Correspondingly, Sims (2012) argued that proper HRM ultimately leads to business success since well-managed employees work efficiently and with utmost productivity towards attaining the business goals. However, prior to the application of the HRM principles, effective recruitment of productive members is important to build an effective set of workforce (Dowling & et. al., 2008). As per the report of CBI (2013), employing graduates from overseas markets not only enhances workplace diversity but also helps companies in the global markets to tackle cultural differences amid customers in an efficient manner. It is through this mechanism that by recruiting skilled and education candidates from numerous regions, companies can ensure compliance with the modern day challenges of diversity and continuous changes (CBI, 2013). As per the study of Hoo & et. al. (2009), in the presence of graduates from the overseas markets, companies are able to better exploit the potentials of the overseas markets and gain better share in the international markets (Hoo & et. al., 2009). Besides, as Al Etihad is among the fastest growing players in Gold and Silver refinery industries, the company requires highly skilled and technically sound employees, capable of dealing with such on-the-job

Emily Dickinson Essay Example for Free

Emily Dickinson Essay Emily Dickinson, one of the best-known American poetesses, was born in Amherst, western Massachusetts in the 1830. The house where poetess spent the greatest part of her lifetime was called the Homestead. It was built in the 1803 by her grandfather, sold and then bought out in the 1855. Her parents both graduated from the Amherst College. Emily’s father was a well-known person in the town, as he was a treasurer of Amherst College (which was earlier co-founded by her grandfather), a good lawyer and he also was a republican representative to the national legislatures. It is said that Emily’s mother didn’t play an important role in her life, as she couldn’t provide her daughter with the amount of emotions and attention she needed. The poetess herself later referred to her as a sort of a person â€Å"to whom you hurry when you are troubled†. Her early years she spent accompanied by her younger sister Lavinia and a brother whose name was Austin. Her parents, who both were the members of the orthodox Congregational Church, tried to make of her an educated and religious woman who someday will have to take care of her own family. But it became evident later that Emily’s individualistic approach to life, her certain personal features didn’t allow her to perform the social role that was prescribed for the women of her social status at that times. Emily received good education, especially for a women living in the 19th century. First she studied in the Amherst women’s academy and than she spent a year in a Mount Holyoke Female Seminary. Both the first and the second educational establishment devoted endless hours to religious edifications, so the poet’s growing up occurred under the severe religious pressure. At the academy she became notorious as one of the few students who refused to admit her faith in Christ on public. This fact darkened her further sojourn in that establishment, as Emily felt alienated and misunderstood at the place, where everybody shared the beliefs she didn’t fully support. Although she participated in the agency of the community of the Christian resurgence, she failed to become a convinced believer and didn’t join the church community. In 1955 during Emily’s travel to Washington to visit her father, who was a congressman at that period, she stopped at Philadelphia to listen the sermon of the known priest whose name was Charles Wadsworth. She corresponded with him for a long period of time and he is presumed to be Emily’s first love, one of her deeply hidden romantic disappointments which inspired her writings. Another Emily’s presumable object of passion was Samuel Bowles, the editor of the â€Å"Springfield Republican†. Today some researchers say that Dickinson stayed unmarried because of the well hidden passion she had for women. They support their viewpoint giving the feministic analysis of her verses. They also note that Emily kept very close relationship with some of her friends who were woman, and only the strict traditions and beliefs of her time didn’t allow Emily to reveal her real passions. These researchers give us the information that the poetess’s letters to her friend and sister-in-law Susanne Gilbert were thoroughly edited before publishing by her niece, to exclude all the â€Å"passionate love confessions† from there. Other scientists explain the fact of Dickinson being single by some of her personal traits which made marriage undesirable for her. Emily was said to be very careful choosing friends and some people think that she just couldn’t find a man she could live with. Some of the researchers think that the poetess’s desire to stay unmarried was dictated by the customs which existed in the USA at those times. It was acceptable for a women to stay a spinster and to â€Å"keep the house† for the rest of her life. So, both Emily and her sister Lavinia didn’t have husbands. The only member of that family whose love life was successful was their brother Austin. He married a â€Å"genteel† girl from New-York, Susanne Gilbert who later became one of the closest Emily’s friends. Dickinson kept corresponding with some of her friends and relatives for all her life. What is interesting is that she often wrote and received letters from her next door neighbor Susanne Dickinson, her brother’s wife. Emily’s letters are a valuable source that provides us with the information about her personality, character, and attitudes and, what is also important, her life patterns. Emily’s most productive years were 1858-1863, when the number of the poems written enlarged from 52 in the 1858 to the 366 in the 1852. Researches strongly argue on the reason of such productivity increase and most of them agree that there was some failed love affair in Emily’s life in the late fifties. The efforts to define the object of her interest failed. Assumptions made on this topic touched almost everybody with whom Emily communicated closely, including her brother, Susan Gilbert, her sister-in-law, Thomas Wentworth Higginson, Judge Otis Lord, Charles Wadsworth and her friend Kate Scott Anthon, but no evidence of Dickinson having a romantic affair with anyone of these people is not found yet. It is known that Emily didn’t strive for the publicity at all. Only ten of her verses were published during her life and all of these under the pseudonym. Some even think that the poetess didn’t give her permission for the publication. A data exists that she was offered by Thomas Niles of Roberts Brothers publishing house to publish her book in 1883 but refused him. It is presumed that Emily valued her privacy very much and she didn’t like the idea of becoming a well-known person. Instead of printing and publishing her books Emily Dickinson made manuscripts, which were later called fascicles, by herself. She begun to make them in 1958 and only death stopped her work. She shared her work in the narrow circle of her friends and relatives. Emily Dickinson was known for being an eccentric person throughout the dwellers of Amherst. From the 1970 she never wore anything except white dresses and she rarely went out of her yard. The poet rarely communicated with anyone except her family and those who wanted to talk to her had pass the â€Å"face-control† made by her sister Lavinia on Emily’s request. It seems that her inner world was so tender and vulnerable that it was hard for her to let a new person to enter there. Emily chose her surroundings carefully, but she gave all her love and affection to those whom she found worthy of trust. Emily died in the 1886, presumably of some kind of kidney’s disease. Her sister was astonished when she found more than a thousand verses stashed in the wooden bureau in Dickinson’s cabinet. Three volumes of Emily’s poems were published by Lavinia, but she of course couldn’t enjoy her triumph or oppose to those who criticized her. But it seems to me it wouldn’t grieve her, as she said everything she wanted to say in her verses. She made her manifest to the world and now it’s our turn.

Functional Groups of Lisinopril

Functional Groups of Lisinopril The IR spectra of pure showed peaks at which are consistent with the presence of the functional groups of lisinopril (Fig.no.12) Furthermore, the calibration curve of lisinopril obeyed Beers law in the range of 10-60 g/ml (Fig.no.11) An IR spectrum of the drug-polymer (methylcellulose) mixture was taken to study and check the drug- polymer interaction. The spectrum revealed that not much interaction between the drug and polymer (Fig.no.13). In TLC studies, the prepared lisinopril microspheres (M4, M7) showed (Table.no.9) the same Rf (0.5512, 0.5769) value as pure compound (0.5897) and no additional spots were detected. TLC studies (Fig.no15) thus indicated no interaction between lisinopril and polymer (methylcellulose) in the floating microspheres prepared. This observation also indicated that lisinopril was not decomposing during the preparation of floating microspheres. Differential Scanning Colorimetry: The thermal behavior of floating microspheres of lisinopril was studying using DSC are shown in (Fig no.16). The DSC thermogram of pure drug lisinopril exhibited an exothermic peak at corresponding to its melting point. For formulation (M7) this peaks are at respectively. The characteristic exothermic peak is slightly shifted to lower temperature, indicating that there is no interaction between drug and carrier. Percentage yield: Percentage yield of different batches of the prepared floating microspheres were determined by weighing the floating microspheres after drying. All batches of methylcellulose floating microspheres showed a percentage yield of greater than 75%, the percentage yields of all the prepared formulations (M1-M9) were in the range of 76.8 to 92.16% (Table.no.11). Percentage yield is found to be higher with formulation M7 (92.16%). Scanning Electron Microscopy: The surface morphology of the prepared floating microsphere (M7) was shown to be spherical by the SEM photography (Fig.no.19). Particle size analysis: The particle size analysis was carried out using an optical microscope. The arithmetic mean particle size of the methylcellulose floating microspheres significantly increased with increasing polymer concentration were shown in (Table.no.18).The particle size distribution of the methylcellulose floating microspheres ranged between 163.125 to 252.375Â µm. Micromeritic properties of the floating microspheres 61 The various micromeritic properties of the prepared floating microspheres were studied. Acceptable range of angle of repose is between 20ÃŽ ¿-40ÃŽ ¿ and angle of repose for methylcellulose floating microspheres (M1-M9) was between 24.44 to 35.53ÃŽ ¿ (Table no. ), thus indicating good flow property for methylcellulose floating microspheres. Acceptable range of Hausners ratio is up to 1.25 and Hausners ratio for methylcellulose floating microspheres(M1-M9) was between 1.085 to 1.181(Table.no.21) ,all the prepared floating microspheres had a value less than 1.25 thereby exhibiting good flow properties. Acceptable range of Carr,s index (%)is up to 5-21%, and carrs index for methylcellulose floating microspheres(M1-M9) was between 7.910 to 15.379 % (Table.no.21) all the formulations showed an Carr,s index (%) less than 16% and hence had a flow properties. Percentage drug content of the floating microspheres The percentage drug content of different batches of floating microspheres was found in the range of 55.33 to 88%.All batches of the methylcellulose floating microspheres formulation shown percentage drug content more than 55% (Table no.23) and it is found that percentage drug content increases with an increase in the polymer concentration (except M2,M6). Formulation M5 has shown maximum percentage drug content (88.0%). Buoyancy percentage: (Floating ability) The buoyancy test was carried out to investigate the buoyancy percentage (floating ability) of the prepared methylcellulose floating microspheres. The buoyancy percentage of the different batches of floating microspheres was found in the range of 48.0 to 85.0% at the end of 12 hrs (Table.no.25). All the formulated floating microspheres of lisinopril showed buoyancy (floating ability) more than 48%. Amongst the batches of prepared methylcellulose floating microspheres, batch M5 showed highest buoyancy (85%). Floating ability of different formulations was found to be differed according to the increase polymer concentration and it is found that percentage of buoyancy increases with an increase in the amount of polymer. In-vitro release studies Lisinopril release from the all formulated floating microspheres were studied in SGF (0.1N HCl) for 12 hrs.The floating microspheres showed sustained release of the lisinopril (drug) in acidic environment and the drug release was found to be approximately linear (fig no. ). The drug release from methylcellulose floating microspheres was found to be 82.35, 78.75, 74.25, 71.55, 66.15, 83.70, 90.45, 94.5 and 97.65% at the end of 12 h for M1,M2,M3,M4,M5,M6,M7,M8 and M9 respectively (Table.no.27). The sustained release pattern was observed for the prepared floating microspheres (M1-M9) clearly exhibiting an increase in the polymer concentration results decrease in-vitro drug release of lisinopril. Amongst the batches of prepared methylcellulose floating microspheres, batch M5 showed higher drug entrapment efficiency 88.0% and the minimal in-vitro drug release 66.15% at the end of the 12 hrs with compared to the other prepared methylcellulose floating microspheres. Drug release kinetics The results for the mathematic modeling of the in-vitro drug release data for the methylcellulose floating microspheres have been complied and the R2 values shown in the table no. The in-vitro drug release profile for the formulations M1-M9 were subjected to various drug release kinetic studies and are depicted in the following figures. (Fig.no.30-38) The release profile for the formulations M1-M9 exhibiting a maximum R2 values (0.9613, 0.9421, 0.9386, 0.9446, 0.9382, 0.9546, 0.9520, 0.9599 and 0.9660) was found to obey that particular kinetics. From the results it is apparent that the regression coefficient value closer to unity as in the case of the Zero orders plots. The Zero order plots of different formulation were found to be fairly linear, as indicated by their high regression values. Thus, it seems that drug release from the floating microspheres followed Zero order kinetics. The data indicates a lesser amount of linearity when plotted by the First order equation. Hence it can be concluded that the major mechanism of drug release follows Zero order kinetics. Further, the conversion of the data from the dissolution studies suggested possibility of understanding the mechanism of drug release by configuring the data into various mathematical modeling such as Higuchis and Korsemeyers -peppas plots. The mass transfer with respect to square root of time has been plotted, revealed a linear graph with regression value close to one stating that the release from the matrix was through diffusion. Data based on the Higuchi model usually provide a evidence to the diffusion mechanism of drug release from matrix systems such as the methylcellulose floating microspheres developed in this work. R2 values based on the Higuchis model ranged from 0.8882, 0.8578, 0.8507, 0.8603, 0.8542, 0.8773, 0.8708, 0.8858 and 0.8978. (Table.no.29). As these values were close to 1.0, the drug release mechanism of the developed floating microspheres can be said to be Higuchian and, therefore, matrix diffusion-controlled. CHITOSAN FLOATING MICROSPHERES IR Spectra of chitosan floating microspheres An IR spectrum of the drug-polymer (chitosan) mixture was taken to study and check the drug- polymer interaction. The spectrum revealed that not much interaction between the drug and polymer (Fig.no.14). Thin Layer Chromatography: In TLC studies, the prepared lisinopril microspheres (C4, C7) showed the same Rf (0.5384, 0.5000) value as pure compound (0.5897) and no additional spots were detected(Fig.no.15). TLC studies thus indicated no interaction between lisinopril and polymer (chitosan) in the floating microspheres prepared. This observation also indicated that lisinopril was not decomposing during the preparation of floating microspheres. Differential Scanning Colorimetry: The thermal behavior of floating microspheres of lisinopril was studying using DSC are shown in Fig.no.17. The DSC thermogram of pure drug lisinopril exhibited an exothermic peak at corresponding to its melting point. For formulation (C7) this peaks are at respectively. The characteristic exothermic peak is slightly shifted to lower temperature, indicating that there is no interaction between drug and carrier. Percentage yield: Percentage yield of different batches of the prepared floating microspheres were determined by weighing the floating microspheres after drying. All batches of methylcellulose floating microspheres showed a percentage yield of greater than 75%, The percentage yields of all the prepared formulations (C1-C9) were in the range of 78.0 -93.66% (Table.no.12). Percentage yield is found to be higher with formulation C7 (93.66%). Scanning Electron Microscopy: The surface morphology of the prepared floating microsphere (C7) was shown to be spherical by the SEM photography (Fig.no.20). Particle size analysis: The particle size analysis was carried out using an optical microscope. The arithmetic mean particle size of floating microspheres significantly increased with increasing polymer concentration were shown in Table. No. 19. The particle size distribution of the chitosan floating microspheres ranged between 32.50 to 55.80Â µm. Micromeritic properties of the floating microspheres 61 The various micromeritic properties of the prepared floating microspheres were studied. Acceptable range of angle of repose is between 20ÃŽ ¿-40ÃŽ ¿ and angle of repose for chitosan floating microspheres (C1-C9) was between 19.02 to 23.49ÃŽ ¿ (Table.no.22), thus indicating good flow property for chitosan floating microspheres. Acceptable range of Hausners ratio is up to 1.25 and Hausners ratio for chitosan floating microspheres(C1-C9) was between 1.100 to 1.230 (Table.no.22) ,all the prepared floating microspheres had a value less than 1.25 thereby exhibiting good flow properties. Acceptable range of Carr,s index (%)is up to 5-21%, and carrs index for chitosan floating microspheres(C1-C9) was between 9.090 to 18.746% (Table.no.22) all the formulations showed an Carr,s index (%) less than 18% and hence had a flow properties. Percentage drug content of the floating microspheres The percentage drug content of different batches of floating microspheres was found in the range of 50.66 to 88.0%.All batches of the chitosan floating microspheres formulation shown percentage drug content more than 50% (Table.no.24) and it is found that percentage drug content increases with an increase in the polymer concentration. Formulation C5 shown maximum percentage drug content (88.0%). Buoyancy percentage: (Floating ability) The buoyancy test was carried out to investigate the buoyancy percentage (floating ability) of the prepared chitosan floating microspheres. The buoyancy percentage of the different batches of floating microspheres was found in the range of 46.0 to 82.0% at the end of 12 hrs (Table.no.26). All the formulated floating microspheres of lisinopril showed buoyancy (floating ability) more than 46%. Amongst the batches of prepared chitosan floating microspheres, batch C5 showed highest buoyancy (85%). Floating ability of different formulations was found to be differed according to the increase polymer concentration and it is found that percentage of buoyancy increases with an increase in the amount of polymer. In-vitro release studies Lisinopril releases from the all formulated floating microspheres were studied in SGF (0.1N HCl) for 12 hrs.The floating microspheres showed sustained release of the lisinopril (drug) in acidic environment and the drug release was found to be approximately linear (Fig.no.29). The drug release from chitosan floating microspheres was found to be 66.6, 61.65, 58.95, 57.15, 52.2, 69.3, 71.55, 74.7 and 78.75% at the end of 12 h for C1,C2,C3,C4,C5,C6,C7,C8 and C9 respectively (Table.no.28). The sustained release pattern was observed for the prepared floating microspheres (C1-C9) clearly exhibiting an increase in the polymer concentration results decrease in-vitro drug release of lisinopril. Amongst the batches of prepared chitosan floating microspheres, batch C5 showed higher drug entrapment efficiency 88.0% and the minimal in-vitro drug release 52.2% at the end of the 12 hrs with compared to the other prepared chitosan floating microspheres. Drug release kinetics The results for the mathematic modeling of the in-vitro drug release data for the methylcellulose floating microspheres have been complied and the R2 values shown in the table no. The in-vitro drug release profile for the formulations C1-C9 were subjected to various drug release kinetic studies and are depicted in the following figures. (Fig.no.39-47) The release profile for the formulations C1-C9 exhibiting a maximum R2 values (0.9834, 0.9646, 0.9556, 0.9244, 0.9305, 0.9656, 0.9655, 0.9646, and 0.9759) were found to obey that particular kinetics. From the results it is apparent that the regression coefficient value closer to unity as in the case of the Zero orders plots. The Zero order plots of different formulation were found to be fairly linear, as indicated by their high regression values .Thus, it seems that drug release from the floating microspheres followed Zero order kinetics. The data indicates a lesser amount of linearity when plotted by the First order equation. Hence it can be concluded that the major mechanism of drug release follows Zero order kinetics. Further, the conversion of the data from the dissolution studies suggested possibility of understanding the mechanism of drug release by configuring the data into various mathematical modeling such as Higuchis and Korsemeyers -peppas plots. The mass transfer with respect to square root of time has been plotted, revealed a linear graph with regression value close to one stating that the release from the matrix was through diffusion. Data based on the Higuchi model usually provide a evidence to the diffusion mechanism of drug release from matrix systems such as the chitosan floating microspheres developed in this work. R2 values based on the Higuchis model ranged from 0.9238, 0.8905, 0.8751, 0.8295, 0.8392, 0.8955, 0.8993, 0.8986 and 0.9236. (Table.no.30). As these values were close to 1.0, the drug release mechanism of the developed floating microspheres can be said to be Higuchian and, therefore, matrix diffusion-controlled.